Beta-secretase 1

The family

Identity ≥30%

Method

Include orthologues chimeras & fusions ligand-bound only ligand-free only

Dossier

Entries

Coverage and disorder

Two different questions on one axis: what was in the construct, and what was actually resolved

Rarely resolved regions

Present in the crystal, absent from the density

Conservation

Sequence logo

Positions people deliberately mutate

Wild type still dominant, but a real minority carries something else. Ranked by how much of the family is substituted

Seed sequence

Coloured by how often each residue is resolved

Construct coverage

How many of the family's constructs contain each residue of the seed

What people actually made

Domain architecture

Orthologues

Which organisms have structures, at what coverage and quality

Structure viewer

Pick an entry to load the viewer.

Mol* is fetched on demand (5 MB, once per visit) and reads structures straight from the RCSB, so nothing is downloaded or stored by this server.

Pairwise TM-score matrix

Cut 0.18

Chemical components

Hot residues

Interaction fingerprint

Ligand × residue, across the family

What actually worked

Conditions

Best resolution achieved with each, across the family

The family

Coverage and disorder

Rarely resolved regions

Conservation

Sequence logo

Positions people deliberately mutate

Seed sequence

Construct coverage

What people actually made

Domain architecture

Orthologues

Structure viewer

Pairwise TM-score matrix

Chemical components

Hot residues

Interaction fingerprint

What actually worked

Conditions

Which entries to trust

What it assembles into

Fold topology

Fold diagram

What it is called

Who works on it

Functional sites

Drugs in this pocket